Slow-growing babies more likely in normal-weight women; Less common in obese pregnancies

ScienceDaily (Apr. 27, 2012) ? Obesity during pregnancy puts women at higher risk of a multitude of challenges. But, according to a new study presented earlier this month at the American Institute of Ultrasound in Medicine annual convention, fetal growth restriction, or the poor growth of a baby while in the mother's womb, is not one of them. In fact, study authors from the University of Rochester Medical Center found that the incidence of fetal growth restriction was lower in obese women when compared to non-obese women.

Researchers, led by senior study author and high-risk pregnancy expert Loralei Thornburg, M.D., conducted the study because a wealth of data shows that obese women are at greater risk of fetal death or stillbirth. Unfortunately, in the majority of cases, doctors don't know why. Thornburg's team wanted to determine if fetal growth restriction -- which increases the likelihood of stillbirth -- might play a role. She says growth restriction may go undiagnosed in obese women because it can be difficult to get an accurate measure of mom's belly size, which is a tool used to gauge the baby's growth -- or lack of growth.

"We wondered if the increased risk of stillbirth could be due to a high level of undiagnosed growth restriction -- the idea being that if the physician doesn't know that the baby is too small then they don't know that mom and baby need additional monitoring, which is essential to prevent fetal death," said Thornburg, an assistant professor in the Department of Obstetrics and Gynecology at the Medical Center whose research focuses on obesity in pregnancy.

The team, including lead study author and Maternal-Fetal Medicine Fellow Dzhamala Gilmandyar, M.D., found that growth restriction was significantly lower in obese and diabetic women; it was higher in women with preeclampsia, or pregnancy-induced high blood pressure, and smokers -- a finding in line with past research. Of the babies that had growth restriction, they determined how many moms were given an accurate diagnosis before birth and found that the rate was the same for obese and non-obese women, suggesting that missed diagnoses are not a major problem in obese pregnancies.

"Our results defeat the idea that undiagnosed growth restriction is behind increased rates of fetal death in obese women," noted Thornburg. Many obese women also have diabetes, which could influence the risk of fetal death, but more research is needed to understand whether or not that is the case.

Though stillbirth, most often defined as death occurring after 20 weeks gestation, is not very common in the general population -- it occurs in around six of every 1,000 births in the U.S., according to the Centers for Disease Control and Prevention -- it is more common in specific populations, including obese women, African Americans and teens.

While the cause of stillbirths in obese women remains elusive, Thornburg says "One thing we do know is that we are not just dealing with obesity in pregnancy anymore. We are seeing a real increase in extreme obesity, which may represent a different condition altogether, so we need to look at moderate obesity compared to severe, morbid obesity."

Thornburg and Gilmandyar reviewed birth record data from more than 16,000 women who delivered at the Medical Center between 2000 and 2010. Obesity was defined as having a pre-pregnancy body mass index or BMI of 30 or greater and growth restriction was defined as being below the tenth percentile of expected birth weight for gestational age. After taking into account the effects of diabetes, high blood pressure and tobacco use, growth restriction remained lower in obese women (8.5 percent) compared to non-obese women (nearly 10 percent).

"While our study shows that obesity by itself may not be a risk factor for growth restriction, it is still important to closely monitor women who also have high blood pressure or who are smokers, because these are established risk factors for growth restriction," said Gilmandyar, who is completing her second year as a fellow at the Medical Center.

In addition to Gilmandyar and Thornburg, Kristin Knight, M.D., Maureen Perdue, M.D., Oluwateniola Brown, Tina Jensen, David Hackney, M.D., and Eva K. Pressman, M.D., from the Medical Center contributed to the research.

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The above story is reprinted from materials provided by University of Rochester Medical Center.

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Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

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User:LIdijJa2 - PerAds

From PerAds

Internet marketing - Podcasts As well as Article promotion

When I first began online, I used to be inundated through the variety of increasing visitor count strategies on the market. I can remember where I needed a list of Seventy methods for getting visitors, however had no place to begin with. I was thinking in order to me personally, "Great! Now just about all I need to perform is actually do these types of 75 weekly, and I will start making many people to my own web site." Unfortunately, this was incorrect.

It took me quite a long time to find a traffic system for myself i can use to get people to my website, and obtain these phones buy something through myself. Now the site visitors program i have formulated personally is something that you could depend on Two fingers. We just have concerning Ten techniques i use each week, plus they do a sufficient job associated with getting me personally the site visitors that i am trying to find.

In the current session, I want to give you some regarding my internet marketing traffic program so that you can make use of them and also replicate the outcomes that I am obtaining of your stuff. They are quite simple and simple to utilize, but you should have no issue applying these inside your company these days.

Here's the very first idea so you can get visitors to your internet site:

1) website marketing

I love podcast marketing and advertising. You could start a podcast weblog and create a merchant account with a internet site called "Feedburner", and you can start your own personal podcast marketing and advertising program this way. You will want to submit the podcast website to all of the website sites, and you may desire to publish the blog's RSS feed to all or any with the Feed directories.

But you simply have to do that as soon as. When it is within, it's inside forever. Right now some blog sites will not take your site in to addition of their website. But that's alright... there are many weblog websites that you can submit to, and you ought to focus the energies about those that may accept your blog.

Making the actual podcast is simple. All you need is any mic and a documenting software, and you're simply good to go. Podcasts don't take long to produce, and they are a very good way to find the phrase out there about your company. Just be sure to talk about your website at the start as well as finish of your podcast.

Here's an additional site visitors approach:

2) seo marketing

I love marketing with articles because it brings you a lot associated with visitors to your website merely and easily. It's very simple to do additionally. Merely write up any Four hundred in order to Five-hundred word post as well as publish them to the article submission sites. You will get search engine traffic, you will get site visitors through people searching for the sort of articles around the article directory itself, and you may get site visitors through those people who have the permission to adopt your own article as well as post that on their website.

It may be extremely powerful technique should you stick with it. It's something that does not demand a great deal of work. If you're able to compose 1 to 2 articles per day, then you're on course. Soon you'll find your self turning into abundant together with your article marketing, and you will be cranking away write-up simply and easily on a daily basis.

These Two methods for traffic generation to your site are usually items that you should determine that you need to hold the utmost chances of good results inside your web business. Consider these tips and use these to create the kind of cash that you are trying to find within your enterprise these days.

The thought of internet marketing is definitely not misplaced upon any person today. Even someone who is fairly new to the web might usually a short time to comprehend what the whole thing is focused on. Basically, the particular idea of internet marketing is not that difficult to understanding. That usually merely handles anything that is because of the particular advertising of products or perhaps solutions online. However, when you are right down to the actual meat from the matter, you may arrive at discover the concept additionally holds all the other facets of marketing and advertising including customer support as well as connection.

This kind of being the case, you can also suppose wanting to end up part of the internet corporate environment is similar to opening a business inside real. The huge difference is actually obviously, inside the signifies utilized to market and sell these products. But the fundamentals of selling for example design, improvement, ad, and sales still need be viewed. This is the same for that concepts associated with consumer engagement and crm. In other words, just because to control your emotions on the web does not imply that company ethics and also manners needs to be dismissed or perhaps downplayed.

Trying internet marketing by itself, there are a variety regarding techniques on the internet entrepreneurs use so that you can gain internet visibility. Your competitors is simply as feel, if not tougher, since the genuine company arena. Therefore, you need to perform equally as difficult as well as harder so that you can define your market and also overcome your competitors. The more common techniques used so far as internet marketing can be involved are search engine marketing techniques or even seo, linking, e-mail marketing, cell advertising, banner ad campaigns, as well as newsletters. Besides these, internet businesses are extremely asked to take part in affiliate marketing programs to be able to seize the wider audience.

With all the rise associated with social media websites, social media has clearly turn out to be among the best techniques also to market a person's products and services in particular and also gain on the internet recognition generally speaking. You will recognize that company that setup web sites try to create accounts in the more renowned social networking sites for example Tweets, Myspace, LinkedIn, plus a quantity of other people. The point is basically similar because once you buy marketing providers in genuine. Moreover, much like doing work in person, you also need to employ the assistance of marketing and advertising specialists.

Keep in mind that the web is an even bigger place to overcome. If you are a newbie merely wanting to obtain ground in the internet business market, you will be suffocated by loads of some other sites having the same profession when you carry out. It's a wise investment to carefully select your own internet marketing techniques and also employ a expert to assist you gain online visibility. There are many resources you may use, through computer software down to other business designs to help make your internet site interest the proper audience. Nevertheless, it is strongly suggested to let a professional take the reins should you really want to get your company on an effective start.

Good luck with with such suggestions to earn more money simply and simply with social media marketing!

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Immigration Law Tips ? Accurate Information | Articles about law ...

If you are not a resident of this country, you will want to make sure that you are getting only the best immigration law tips. As a matter of fact, without having some smart and accurate immigration tips to help guide you through the process, you are going to end up making some mistakes that can put you in a very difficult situation. We all know about the infamous ways that people try to gain instant citizenship. For example, some people get married to receive green cards, while others will try to stay in education programs. In many cases, these methods are legitimate, but sometimes there are smarter ways to stay in the country.

The first of the immigration law tips that you need to keep in mind is that you are supposed to have a reason to be in the country if you plan on staying for more than just a few months. In many cases, the reason people are in the country from afar is for work or education reasons. If you would like to stay in the country after your temporary visa runs out, then you will need to make sure that you are filing out the proper paperwork. Some people might also need to finish language tests to earn the proper certification for staying in the country. In all instances, it is necessary that you are able to sit down with a professional who is familiar with the law

If you are new to the country and don?t understand English that well, then you will want to enlist some help when you are trying to find the best immigration law tips. The truth of the matter is that there are a lot of false ideas out there that get spread around on the internet. You want to make sure that you are up to date with all of your paperwork and that you are submitting the correct forms to the correct offices.

For many people, the only way safely to get the best immigration law tips is to work with a knowledgeable and experienced immigration lawyer. This means that you will want to find a legal professional who is quite familiar with immigration law as it related to both state and federal standards. It?s also important that you have an attorney who will sit down with you for free and who will make sure that he or she actually can help you.

Tags: immigration attorney, immigration law, immigration law information, immigration law tips, immigration lawyer

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Vision Insurance Do You Need It?

Whereas It?s undoubtedly essential to have healthy eyes, it might or may not be crucial to have vision or eye insurance. Many of us overvalue this insurance coverage and overpay.

To know whether or not you a dollars price of protection for every dollar spent when you spend money on eye care protection, it?s crucial to know what eye coverage covers and what it would not cover. Having data of the limitations of vision coverage is critical to determine whether it?s best to pay extra for the coverage.

It would be best to know what the extra protection will include. Vision coverage covers expenses which are related to contact lenses or eye glasses. Typically optical coverage will cover a watch examination. It could also cowl part of the cost of contact lenses or prescription glasses.

You also needs to know what it doesn?t cover. eye or imaginative and prescient protection doesn?t cover the medical fees associated with a watch harm or illnesses that influence the eye. Medical insurance coverage will usually cover these health care fees.

Neither your vision protection nor your medical coverage is more likely to embody coverage for LASIK surgery. Surgery to improve vision is normally specifically excluded by well being protection policies. This is completely different from surgical procedure to repair your eyes.

The standard medical coverage policy will not have coverage for corrective lenses. Typical medical protection policies do not cover for the eye examinations that are needed to correctly prescribe corrective lenses. Corrective lenses could be both prescription contact lenses or prescription glasses.

Expenses associated with eye trauma and eye ailments are still paid for as part of the medical benefit. A separate eye protection rider is just not necessary to have eye trauma covered. Many individuals pay extra for eye or vision protection as a result of they imagine that their medical insurance coverage is not going to cowl something related to the medical care of your eyes.

Pay less than $20/month for Accident Insurance through insurance agency, wellnessplanusa.com, that will help pay for your deductible when you have an accident and are responsible for high out of pocket costs.

When looking at medical insurance insurance policies that include optical insurance coverage, you should definitely see how what is and is not included within the coverage. Since some insurance coverage policies will only cover the price of the exam, these policies are much less priceless than vision plans that will not only cowl the examination but will even pay towards glasses.

One other situation to consider is the availability of eye care professionals. Most insurance coverage policies will limit the places you possibly can go to have your eye examination to community providers. It is best to ensure that there are optometrists or optometrists close to you and that you?ll really feel comfy using these opticians or optometrists.

Don?t pay for eye coverage solely to find that none of the network providers are ones you can or need to use. Usually shoppers will routinely examine to be sure that their docs are on the provider lists, however will forget to check for dentists and optometrists.

Realizing the value of the added protection is important if you will make the right choice. If the optical coverage only contains an annual examination, you need to call a watch physician and find out what an exam costs. If the policy additionally pays one thing towards eye glasses you should add that to the price of the exam. Multiply the fee by the number of relations that shall be covered. Then divide that value by 12 of your policy premiums are being paid monthly. It will mean you can correctly compare the added cost of having optical coverage with the additional expenses for the coverage.

Imaginative and prescient insurance coverage is often worth the added premium, but often it will not be. Generally those purchasing for well being care insurance coverage will evaluate completely different plans which might be otherwise the same and select the one that has eye care insurance coverage without the doing the math. You now know the right way to evaluate insurance policies and solely pay extra if the extra coverage is worth the additional price.
You will discover extra individual imaginative and prescient insurance data as well as get CT medical health insurance quotes on the author, Alston J. Balkcom?s website.

?

This post is written by Nicholas Lee 27

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Loomis 'angry' about wiretapping allegations

METAIRIE, La. (AP) ? Embattled Saints general manager Mickey Loomis had plenty to discuss before Thursday night's NFL draft, even if his club had no first-round pick.

Topics on the table included wiretapping, Drew Brees' contract talks and New Orleans' bounty system. Loomis candidly addressed them all, and more.

.He was "angry" about the recent wiretapping allegations. He was empathetic to fans' concerns over prolonged contract negotiations with Brees. He was prepared to deal with the consequences of the NFL's bounty investigation. And no, he wasn't discouraged by all the recent bad publicity or the fact that head coach Sean Payton has begun serving a suspension that won't end until after the Super Bowl.

Rather, he was confident that the Saints will remain a good team in 2012.

"Obviously, we've had a lot of things happen," Loomis said. "Yes, Sean is missing and we miss him, but we are not unstable. ... We have had 41 wins in the last three years. We are not down. If we are down, I'm happy to be down. We have a good team here and we have great leadership on our team. We have great players."

The Saints have been dealing with the fallout from the NFL's bounty probe since March 2, when the league announced it had found that New Orleans had an improper cash bonus system in place to reward defensive players for hits that hobbled targeted opponents.

As a result, suspensions were handed down to Payton, Loomis and assistant head coach Joe Vitt. The Saints also were docked second-round draft choices this season and next. Because they had already traded this year's first-round pick, they were not slated to draft a player until late in Friday night's third round, 89th overall.

This week, yet another, unrelated allegation of wrongdoing surfaced when an anonymously sourced ESPN report said Loomis' Superdome booth was wired to allow him to eavesdrop on opposing coaches' radio conversations from 2002 to 2004.

"I have never asked for the capability to listen to an opposing team's communications," Loomis said. "I have never inquired as to the possibility of listening in on an opposing team's communications. And I've never been aware of any capability to listen in on an opposing team's communications at the Superdome or at any NFL stadium.

"I don't know who made the allegation. I'm angry about it, frankly," Loomis continued. "It's not true. I have clear conscience. That's all I can say. And look, the people that know me and know me the best have all come to my defense. They've stated to me that's not true. And maybe that has to be good enough."

The Louisiana state police and the FBI have begun a joint investigation of the matter to determine if any state or federal wiretapping laws might have been broken. Loomis, who said he is not sure how else he can clear his name beyond a public denial, said he welcomed authorities' involvement.

While Loomis denied wiretapping allegations, he evaded questions about whether he truly agreed with the NFL's findings in its bounty investigation, saying that the team is moving forward and looking forward to cooperating with Commissioner Roger Goodell's goals to promote player safety.

"The NFL, they made their findings. They made their ruling and there's nothing I can do to change that," Loomis said. "It doesn't really matter if I agree or disagree. We have these penalties that we have to deal with and we are dealing with them."

For failing to put a stop to the bounty program after he was first warned the NFL was looking into it in 2010 Loomis will serve an eight-game suspension that will in fact span nine weeks because the Saints' bye falls in Week 6. Loomis said most of his work in a typical season is usually done by opening day and that his staff should be able to absorb his responsibilities during his suspension because "they know exactly how I think."

Loomis added he has offered to spend his half-season absence from the Saints working with the NFL on developing policies to further promote player safety.

"I think I would have some valuable contributions in that regard," he said.

Vitt, who also oversees linebackers, must serve a six-game suspension in connection with the bounty probe. Despite his suspension, Vitt has been tapped to take over Payton's head coaching duties, meaning someone will then have to step in for him in Week 1.

Who that will be has yet to be decided.

"We are going to let probably most of our training camp unfold and I think the right person will kind of reveal itself," Loomis said. "We'll make a good decision for those first (six) games."

The Saints are now two weeks into voluntary offseason workouts, and Brees, their star quarterback and unquestioned leader, has stayed away while contract negotiations continue.

Loomis smiled and said the ideal time to get a deal done would be "tomorrow or maybe an hour from now." Then he tried to explain the holdup.

"No one understands better than I how important Drew and (his wife) Brittany have been to the city of New Orleans, our fans and the New Orleans Saints," Loomis said. "His contributions to our success have been invaluable. Unfortunately, I have the task of putting a value on it. But my goal and Drew's goals are the same. It's to get him a contract that he feels good about and gives our team the best opportunity to compete for a championship. It will get done."

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Notre Dame paper examines nanotechnology-related safety and ethics problem

[ Back to EurekAlert! ] Public release date: 27-Apr-2012
[ | E-mail | Share Share ]

Contact: Kathleen Eggleson
eggleson.1@nd.edu
574-631-1229
University of Notre Dame

A recent paper by Kathleen Eggleson, a research scientist in the Center for Nano Science and Technology (NDnano) at the University of Notre Dame, provides an example of a nanotechnology-related safety and ethics problem that is unfolding right now.

The world of nanotechnology, which involves science and engineering down at billionths-of-a-meter scales, might seem remote.

But like most new advances, the application of that technology to everyday experience has implications that can affect people in real ways.

If not anticipated, discussed or planned for, some of those implications might even be harmful.

The problem that Eggleson describes is that hospital-acquired infections are a persistent, costly, and sometimes fatal issue. A patient goes in for one condition, say an injury, but ends up being infected by a microorganism picked up in the hospital itself. That microorganism might even have developed a resistance to conventional drug treatments.

The solution is that engineers are developing new and innovative ways of coating medical materials with nano-sized particles of silver, an element that has long been known for its antimicrobial properties. These particles are being applied to hard surfaces, like bedrails and doorknobs, and to fabrics, such as sheets, gowns, and curtains, by a growing number of medical supply companies. And these new materials are proving effective.

"Nanosilver coatings have made life-saving differences to the properties of typical hospital items," says Eggleson. "Just this last December, a textile made by a Swiss company was the first nano-scale material approved as a pesticide by the EPA."

The possible new danger is that the vast majority of bacteria and other microorganisms are actually neutral, or even beneficial, to human life and a healthy environment. For example, some bacteria are needed to maintain appropriate levels of nitrogen in the air, and others, living inside the human body, are critical to both vitamin synthesis and digestion.

So overuse of nanosilver products, especially outside of clinical environments, could pose a danger to needed microorganisms, and enable resistant strains to flourish.

"Under most conditions, the preservation of microbial biodiversity is a benefit," explains Eggleson.

"In fact, those who would use these potent new antimicrobial technologies for frivolous uses, such as for odor control, work directly against the U.S. National Nanotechnology Initiative's goal of responsible nanotechnology development."

Eggleson came to the Center for Nano Science and Technology last year to study and prompt discussion of problems like these.

"NDnano is expanding its scope into studies of the societal impact of nanotechnology," explains Wolfgang Porod, Frank M. Freimann Professor of Electrical Engineering at Notre Dame and director of the center. "This is the background for bringing Kathy on board."

To facilitate such discussion, Eggleson initiated a monthly meeting group, called the Nano Impacts Intellectual Community, which brings together Notre Dame researchers from across campus, visiting scholars and authors from outside the university, and leaders from the local area to probe nanotechnology topics in depth.

The group has tackled such issues as the ethics of nanomedicine, the commercialization of nanotechnology products, and the interdisciplinary nature of nanotechnology research.

"I appreciate being a part of this on-going conversation," says Glenn Killoren, an attorney at Barnes & Thornburg LLP and a regular Nano Impacts attendee. "Nanotechnology isn't just something that happens in research labs anymore. It's a small but growing part of our lives, and both scientists and non-scientists need to think about its effects."

Eggleson and NDnano faculty have also met with a number of local middle school and high school teachers who feature nanotechnology in their lesson plans. Moreover, the center supports Ivy Tech Community College-North Central's program to train aspiring nanotechnology technicians.

"We try to do as much as we can to engage the community this exciting area," says Eggleson.

###

The University of Notre Dame Center for Nano Science and Technology (NDnano) is one of the leading nanotechnology centers in the world. Its mission is to study and manipulate the properties of materials and devices, as well as their interfaces with living systems, at the nano-scale.

The center's expanding work on the societal impacts of nanotechnology has been made possible, in part, by one of the university's Strategic Research Investments (SRIs), which represent a commitment of internal funds and other resources, supplementing funding from external grants and gifts, to advance excellence in research.

In addition, Nano Impacts is supported by the Office of the Provost's Initiative on Building Intellectual Community.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


[ Back to EurekAlert! ] Public release date: 27-Apr-2012
[ | E-mail | Share Share ]

Contact: Kathleen Eggleson
eggleson.1@nd.edu
574-631-1229
University of Notre Dame

A recent paper by Kathleen Eggleson, a research scientist in the Center for Nano Science and Technology (NDnano) at the University of Notre Dame, provides an example of a nanotechnology-related safety and ethics problem that is unfolding right now.

The world of nanotechnology, which involves science and engineering down at billionths-of-a-meter scales, might seem remote.

But like most new advances, the application of that technology to everyday experience has implications that can affect people in real ways.

If not anticipated, discussed or planned for, some of those implications might even be harmful.

The problem that Eggleson describes is that hospital-acquired infections are a persistent, costly, and sometimes fatal issue. A patient goes in for one condition, say an injury, but ends up being infected by a microorganism picked up in the hospital itself. That microorganism might even have developed a resistance to conventional drug treatments.

The solution is that engineers are developing new and innovative ways of coating medical materials with nano-sized particles of silver, an element that has long been known for its antimicrobial properties. These particles are being applied to hard surfaces, like bedrails and doorknobs, and to fabrics, such as sheets, gowns, and curtains, by a growing number of medical supply companies. And these new materials are proving effective.

"Nanosilver coatings have made life-saving differences to the properties of typical hospital items," says Eggleson. "Just this last December, a textile made by a Swiss company was the first nano-scale material approved as a pesticide by the EPA."

The possible new danger is that the vast majority of bacteria and other microorganisms are actually neutral, or even beneficial, to human life and a healthy environment. For example, some bacteria are needed to maintain appropriate levels of nitrogen in the air, and others, living inside the human body, are critical to both vitamin synthesis and digestion.

So overuse of nanosilver products, especially outside of clinical environments, could pose a danger to needed microorganisms, and enable resistant strains to flourish.

"Under most conditions, the preservation of microbial biodiversity is a benefit," explains Eggleson.

"In fact, those who would use these potent new antimicrobial technologies for frivolous uses, such as for odor control, work directly against the U.S. National Nanotechnology Initiative's goal of responsible nanotechnology development."

Eggleson came to the Center for Nano Science and Technology last year to study and prompt discussion of problems like these.

"NDnano is expanding its scope into studies of the societal impact of nanotechnology," explains Wolfgang Porod, Frank M. Freimann Professor of Electrical Engineering at Notre Dame and director of the center. "This is the background for bringing Kathy on board."

To facilitate such discussion, Eggleson initiated a monthly meeting group, called the Nano Impacts Intellectual Community, which brings together Notre Dame researchers from across campus, visiting scholars and authors from outside the university, and leaders from the local area to probe nanotechnology topics in depth.

The group has tackled such issues as the ethics of nanomedicine, the commercialization of nanotechnology products, and the interdisciplinary nature of nanotechnology research.

"I appreciate being a part of this on-going conversation," says Glenn Killoren, an attorney at Barnes & Thornburg LLP and a regular Nano Impacts attendee. "Nanotechnology isn't just something that happens in research labs anymore. It's a small but growing part of our lives, and both scientists and non-scientists need to think about its effects."

Eggleson and NDnano faculty have also met with a number of local middle school and high school teachers who feature nanotechnology in their lesson plans. Moreover, the center supports Ivy Tech Community College-North Central's program to train aspiring nanotechnology technicians.

"We try to do as much as we can to engage the community this exciting area," says Eggleson.

###

The University of Notre Dame Center for Nano Science and Technology (NDnano) is one of the leading nanotechnology centers in the world. Its mission is to study and manipulate the properties of materials and devices, as well as their interfaces with living systems, at the nano-scale.

The center's expanding work on the societal impacts of nanotechnology has been made possible, in part, by one of the university's Strategic Research Investments (SRIs), which represent a commitment of internal funds and other resources, supplementing funding from external grants and gifts, to advance excellence in research.

In addition, Nano Impacts is supported by the Office of the Provost's Initiative on Building Intellectual Community.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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Treasure Coast Real Estate | Acreage Homes For Sale April, 2012 ...

by starfish on April 26, 2012

Find Acreage Homes For Sale and Acreage Home Values. We also have information on mortgages, insurance, movers and other Treasure Coast Real Estate Services for anyone looking to sell or buy a home in beautiful St Lucie COUNTY Florida.

Paul Kitchen and Starfish Team provide clients, family and close friends with professional, honest and dependable service. A resident of Treasure Coast, Paul is extremely familiar with the local neighborhoods including Acreage, school districts and the Treasure Coast Real Estate market in this beautiful Florida town.

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Broker-Owner
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Treasure Coast Real Estate
Treasure Coast Real Estate Blog

Starfish Real Estate

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Scripps Florida scientist awarded $1.5 million to design therapeutics with new RNA approach

[ Back to EurekAlert! ] Public release date: 27-Apr-2012
[ | E-mail | Share Share ]

Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

JUPITER, FL, April 27, 2012 A scientist from the Florida campus of The Scripps Research Institute has been awarded $1.5 million from the National Institutes of Health to develop new computer-driven design methods to find new therapeutics targeting RNA.

Matthew Disney, an associate professor at Scripps Research, is the principal investigator for the four-year study.

RNA was once considered a passive messenger, used only to carry copies of the DNA needed to produce or translate proteins. All that changed when it was found that RNA could produce chemical reactions that, for example, cause proteins to fold into various forms. RNA is an increasingly important potential target for the design of small molecule therapeutics, although methods to design small molecule drugs that bind to RNA and affect its function are still in their infancy.

"The rational design of small molecules that exploit therapeutic targets from genomic sequence was one of the promises of the human genome project, but people had no idea of how to do it," Disney said. "As a result, most targetsespecially RNA targetsrepresent untapped potential."

A computer program created by Disney merges information on the interaction between small molecules (potential drugs) and RNA folds present in segments of the human genome that contribute to specific diseases. Disney said his approach differs from conventional "top-down" methods that normally screen an RNA target against a broad chemical library.

"Our bottom-up approach uses information about the small RNA motifs such as internal loops or hairpins that a small molecule ligand prefers to bind," he said.

Using this method, Disney recently successfully designed several small molecules that are strongly active against myotonic dystrophy type 1, the most common form of muscular dystrophy.

All of the tools in the new study will be available on the Internet, so they can be shared by the RNA community.

###

About The Scripps Research Institute

The Scripps Research Institute is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. Over the past decades, Scripps Research has developed a lengthy track record of major contributions to science and health, including laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. The institute employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientistsincluding three Nobel laureateswork toward their next discoveries. The institute's graduate program, which awards Ph.D. degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu



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[ Back to EurekAlert! ] Public release date: 27-Apr-2012
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Contact: Mika Ono
mikaono@scripps.edu
858-784-2052
Scripps Research Institute

JUPITER, FL, April 27, 2012 A scientist from the Florida campus of The Scripps Research Institute has been awarded $1.5 million from the National Institutes of Health to develop new computer-driven design methods to find new therapeutics targeting RNA.

Matthew Disney, an associate professor at Scripps Research, is the principal investigator for the four-year study.

RNA was once considered a passive messenger, used only to carry copies of the DNA needed to produce or translate proteins. All that changed when it was found that RNA could produce chemical reactions that, for example, cause proteins to fold into various forms. RNA is an increasingly important potential target for the design of small molecule therapeutics, although methods to design small molecule drugs that bind to RNA and affect its function are still in their infancy.

"The rational design of small molecules that exploit therapeutic targets from genomic sequence was one of the promises of the human genome project, but people had no idea of how to do it," Disney said. "As a result, most targetsespecially RNA targetsrepresent untapped potential."

A computer program created by Disney merges information on the interaction between small molecules (potential drugs) and RNA folds present in segments of the human genome that contribute to specific diseases. Disney said his approach differs from conventional "top-down" methods that normally screen an RNA target against a broad chemical library.

"Our bottom-up approach uses information about the small RNA motifs such as internal loops or hairpins that a small molecule ligand prefers to bind," he said.

Using this method, Disney recently successfully designed several small molecules that are strongly active against myotonic dystrophy type 1, the most common form of muscular dystrophy.

All of the tools in the new study will be available on the Internet, so they can be shared by the RNA community.

###

About The Scripps Research Institute

The Scripps Research Institute is one of the world's largest independent, not-for-profit organizations focusing on research in the biomedical sciences. Over the past decades, Scripps Research has developed a lengthy track record of major contributions to science and health, including laying the foundation for new treatments for cancer, rheumatoid arthritis, hemophilia, and other diseases. The institute employs about 3,000 people on its campuses in La Jolla, CA, and Jupiter, FL, where its renowned scientistsincluding three Nobel laureateswork toward their next discoveries. The institute's graduate program, which awards Ph.D. degrees in biology and chemistry, ranks among the top ten of its kind in the nation. For more information, see www.scripps.edu



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AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


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